NFL Week 6 Early Inactives: Kyler Murray OUT for Cardinals! Full Injury Report & Updates (2025)

Breaking News: Kyler Murray OUT! The Arizona Cardinals are facing a tough challenge as they head into Week 6 without their star quarterback, Kyler Murray. This absence throws a major wrench into their plans to snap a three-game losing streak. Can they overcome this significant setback, or will the Colts capitalize on the Cardinals' misfortune? Let's dive into the details and see who else will be sidelined this week across the NFL.

Murray's unavailability stems from a nagging foot injury that kept him out of practice for two days. Despite a limited return to practice on Friday, the Cardinals have officially ruled him out just 90 minutes before their game against the Indianapolis Colts. This late announcement leaves fans scrambling and the Cardinals scrambling even more to adjust their game plan.

Stepping in to fill Murray's shoes is Jacoby Brissett, who will start at quarterback. Backing him up is Kedon Slovis, a recent addition to the active roster from the practice squad. This sudden shift in quarterback leadership presents a significant test for the Cardinals' offense. Will Brissett be able to effectively lead the team against a determined Colts defense?

Here's a comprehensive list of all the early inactives for Week 6:

Cardinals at Colts

  • Cardinals: QB Kyler Murray (foot injury), CB Elijah Jones, DL Darius Robinson, OL Demontray Jacobs, OL Josh Fryar, WR Xavier Weaver, DL Bilal Nichols
  • Colts: RB Tyler Goodson, CB Kenny Moore, TE Will Mallory, WR Adonai Mitchell, QB Anthony Richardson, T Luke Tenuta, DE JT Tuimolau. Note: The absence of QB Anthony Richardson could significantly impact the Colts' offensive strategy.

Rams at Ravens

  • Rams: WR Tutu Atwell, LB Omar Speights, G Beaux Limmer, T Rob Havenstein, TE Colby Parkinson, DE Deshaun Johnson
  • Ravens: QB Lamar Jackson, LB Roquan Smith, CB Chidobe Awuzie, FB Pat Ricard, T Carson Vinson, WR Tez Walker, DT Aeneas Peebles. The Ravens are missing key players on both sides of the ball. How will this affect their performance against the Rams? But here's where it gets controversial... Some analysts argue that the Ravens' depth will allow them to weather these absences, while others believe that the Rams have a golden opportunity to pull off an upset.

Cowboys at Panthers

  • Cowboys: WR CeeDee Lamb, OL Tyler Booker, WR KaVontae Turpin, LB Jack Sanborn, DL Mazi Smith, OL Ajani Cornelius. CeeDee Lamb being out is a big blow to the Cowboy's offense.
  • Panthers: TE Ja’Tavion Sanders, CB Akayleb Evans, RB Chuba Hubbard, S Trevian Thomas, T Taylor Moton, DT Jaden Crumedy, DT Tershawn Wharton. The Panthers' injury list is extensive, further compounding their struggles this season. And this is the part most people miss... The Panthers' offensive line woes could make it incredibly difficult for them to establish any kind of running game.

Seahawks at Jaguars

  • Seahawks: QB Jalen Milroe, S Julian Love, CB Devon Witherspoon, CB Riq Woolen, LB Derick Hall, OL Josh Jones, TE Nick Kallerup. The Seahawks' secondary is significantly weakened with the absence of both Witherspoon and Woolen.
  • Jaguars: S Kahlef Hailassie, RB Cody Schrader, LB Yasir Abdullah, OL Robert Hainsey, DT Khalen Saunders

Chargers at Dolphins

  • Chargers: WR Quentin Johnston, WR Derius Davis (knee), FB/DL Scott Matlock, OL Jamaree Salyer, T Joe Alt, OL Trey Pipkins, CB Nikko Reed. The Chargers' receiving corps is depleted, forcing them to rely on less experienced players.
  • Dolphins: QB Quinn Ewers, RB Jaylen Wright, CB Storm Duck, DT Zeek Biggers, LB Tyrel Dodson, WR Cedrick Wilson Jr., DB Elijah Campbell

Patriots at Saints

  • Patriots: QB Tommy Devito, S Jaylinn Hawkins, LB Anfernee Jennings, DT Eric Gregory, G Caedan Wallace, DE Keion White
  • Saints: S Ugo Amadi, CB Rejzohn Wright, OL Torricelli Simpkins, OL Xavier Truss, DT Khristian Boyd, CB Isaac Yiadom

Browns at Steelers

  • Browns: CB Jarrick Bernard-Converse, RB Raheim Sanders, DT Mike Hall Jr., T Thayer Munford, G Zak Zinter, T Cornelius Lucas
  • Steelers: WR Calvin Austin, S Chuck Clark, DL DeMarvin Leal, DL Logan Lee, OL Andrus Peat

These early inactives will undoubtedly have a ripple effect across the league, impacting game strategies and potentially altering the outcomes of several contests. The Cardinals, in particular, face an uphill battle without Kyler Murray. This is where opinions will likely differ: Do you think the Cardinals can still pull off a win against the Colts with Brissett under center? Or are the Colts now the clear favorites? Let us know your predictions and thoughts in the comments below!

NFL Week 6 Early Inactives: Kyler Murray OUT for Cardinals! Full Injury Report & Updates (2025)
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